The Anatomist by Federico Andahazi.
Here's one to recommend to your grandmother. Physician Mateo Colombo discovers the clitoris, scandalises mediaeval Italy and is banged up in prison for heresy and Satanism.
It's based on a true story, in the sense that Mateo Colombo was a real person, who did some genuinely groundbreaking work in the area of blood circulation, work later built upon by our very own William Harvey. It is also true that he published a work called De Re Anatomica which included mention of "the seat of pleasure" in women, but the claim that this is "the discovery of the clitoris" is somewhat dubious to say the least.
None of which really matters, as this is a work of fiction after all. And a generally pretty entertaining one, though also fairly light and insubstantial. It received a lot of publicity when it was published in Argentina in 1997 as it was awarded a major prize which was then rescinded at the request of the prize sponsor on the grounds that the author was a "Communist porn artist". You can't pay for that sort of advertising, especially when your themes are sex, science and the suppression of knowledge.
That's part of the problem, though - the suppression of knowledge (particularly sexual) and the repression of women in the 16th century are pretty easy targets, and the Mateo Colombo presented here is a strange and enigmatic figure whose motivations are never entirely clear, beyond of course experimenting with the effects of drugs by getting fellated by prostitutes after smearing his penis with belladonna. Then again who hasn't done that? Anyway, it's an entertaining read whose subject matter and the furore surrounding its publication suggest a profundity and significance that probably isn't really justified. Unless of course you're a religious fundamentalist, in which case you'll almost certainly have some sort of aneurysm. Enjoy!
On a more serious note, I say: stimulate her clematis. You can't go wrong!